MFASS: What Three Splice-Variant Rankers Put in the First 100
The baseline, SpliceAI and Pangolin found 61, 64 and 65 disruptions in their top 100 MFASS variants. The differences do not establish a reliable winner.
Tagged
#bioinformatics
3 articles tagged with #bioinformatics.
A Bioinformatician's Guide to Choosing Genomic Foundation Models
A practical guide to selecting genomic foundation models for bioinformatics tasks. Covers ESM-2, DNABERT-2, HyenaDNA, Nucleotide Transformer, scGPT, and Evo with specific recommendations for DNA sequence analysis, protein structure prediction, and single-cell analysis based on hardware requirements, inference speed, and task type.
Why Two Gene Discovery Methods Found Completely Different Genes (And Why That Matters for Your Health)
How gene length, trait specificity, and luck systematically distort which genes we think are important for disease, and what researchers should do about it
